Help → Cannot access 8080 port
Looks like Acronis Backup and Recovery is monitoring that port.
Acronis Backup & Recovery 11
BTW the installer did not offer to configure the Email Accounts. I have Outlook 2010.
Port 8080 is not hard-coded into POPFile, you can configure POPFile to use a different port.
If you are using the Windows version of POPFile there is an easy way to change the port used for the POPFile User Interface. Just make sure that POPFile is not running then run the "adduser.exe" program found in POPFile's program folder (the default locations are "C:\Program Files\POPFile" for 32-bit Windows systems and "C:\Program Files (x86)\POPFile" for 64-bit Windows systems).
The wizard should automatically find your existing POPFile data ('Folder to be used to store the POPFile data') and offer to upgrade it. Clicking "Yes" will display the current port settings. The "User Interface" port list offers 8080, 8081, 9090 and 9091 but you can type in a different port setting if you prefer. Click "Upgrade" to let the wizard update your POPFile configuration to use the new port setting.
It is possible that something is already using ports 8081, 9090 and 9091. If you want to check which ports are free you can use "netstat", as explained in the Connection Problems with POPFile UI troubleshooting page.
Although the installer can detect Outlook 2010 it is unable to configure Outlook 2010 for you.
(Edited to fix the copy-and-paste mixup!)