You'll need several things to get started with POPFile on Windows.
You can make it easier to access POPFile by modifying your hosts file. For example, you could set it so that http://popfile:8080 would launch the POPFile UI by adding this line to your hosts file:
127.0.0.1 popfile
Note that on Windows systems you can use either space or tab characters to create the gap between 127.0.0.1 and popfile (do not use a mixture of spaces and tabs).
The default locations of your hosts file on Windows are:
Windows Vista = C:\WINDOWS\SYSTEM32\DRIVERS\ETC Windows XP = C:\WINDOWS\SYSTEM32\DRIVERS\ETC Windows 2000 = C:\WINNT\SYSTEM32\DRIVERS\ETC Windows 98/ME = C:\WINDOWS
Of course, you can also create a bookmark for POPFile and some mail clients allow access to the POPFile UI within the mail client. See Access POPFile from within Outlook for an example.