About half the spam I get is to various email address other than my email address - i.e. Spammers have used some trickery in the email header to deliver those emails to my inbox - I've been getting round this by creating magnets to sort the most common variants into spam, but the magnet list is getting really long now, and this probably isnt the most efficient way to sort spam.
Therefore, since the To: header does not contain my email address, POPFile could save an awful lot of time and resources by simply letting me create a filter that labels any email not specifically addressed to my email address as something for the spam folder.