Yes. You can use APOP and SSL together with POPFile.
Important Note: Please turn off the APOP and SSL options in your mail client.
If your email client is set to use APOP or SSL
, turn those options off.
Setup your email client to use POPFile as a POP3
proxy as described here
Change the 'User ID' to pop.isp.com:995:user:apop,ssl (where 995 is the port number).